Susan Lee Lindquist


Whitehead Institute for Biomedical Research
Nine Cambridge Center, Room 661
Cambridge, Massachusetts 02142-1479









Postdoctoral Fellow, American Cancer Society
The University of Chicago, Chicago, Illinois


Ph.D. in Biology
Harvard University, Cambridge, Massachusetts


B.A. in Microbiology with High Honors
University of Illinois, Champaign-Urbana, Illinois


Academic Appointments 


Member, Whitehead Institute for Biomedical Research
Director, Whitehead Institute for Biomedical Research, 2001-2004
Professor of Biology, Massachusetts Institute of Technology
Cambridge, Massachusetts


Investigator, Howard Hughes Medical Institute
Whitehead Institute for Biomedical Research and MIT


Associate Member, David H. Koch Institute for Integrative Cancer Research at MIT


Senior Associate Member, Broad Institute of MIT and Harvard
Associate Member, Broad Institute, 2005-2010


Professor, Department of Molecular Genetics & Cell Biology
Investigator, Howard Hughes Medical Institute
The University of Chicago, Chicago, Illinois


Assistant & Associate Professor, Department of Biology
The University of Chicago, Chicago, Illinois


Selected Honors and Awards


Glenn Award for Research in Biological Mechanisms of Aging, Glenn Foundation for Medical Research;
Helis Foundation Award for Parkinson's Disease and Neurodegenerative Research, Diana Helis Henry and Adrienne Helis Malvin Medical Research Foundation;
Vallee Visiting Professor Award;
Vanderbilt Prize for Women’s Excellence


DART/ New York University Biotechnology Award for Basic Biotechnology, New York University School of Medicine;
Howard Taylor Ricketts Award, University of Chicago


E.B. Wilson Medal, American Society for Cell Biology


Elected to European Molecular Biology Organization, Associate Member (USA)


National Medal of Science (2009);
Mendel Medal, Genetics Society UK;
Max Delbrück Medal, Berlin;
Doctor of Science honoris causa, Harvard University


Federation of American Societies for Experimental Biology Excellence in Science Award


Genetics Society of America Medal for Outstanding Contributions to the Field of Genetics;
Harvard Centennial Medal 


Fellow, Radcliffe Institute for Advanced Study


Elected to the Institute of Medicine of the National Academies


Elected to the American Philosophical Society


Dickson Prize in Medicine


Novartis/Drew Award in Biomedical Research


Elected to the National Academy of Sciences


Elected to the American Academy of Microbiology


Elected to the American Academy of Arts & Sciences


Recent Honorary Lectures


Plenary Lecture, AAAS Annual meeting, Chicago;
Keynote Lecture, Chicago Society for Neuroscience Meeting, Chicago, IL;
30th Annual Cynthia Ann Chan Memorial Lecture, University of Berkeley, Berkeley, CA;
Keynote Address, International Society for Stem Cell Research, Vancouver, Canada


Keynote Address, Keystone Symposium Santa Fe, NM;
James F "Paulo" Dice Memorial Lecture, Tufts Medical School;
DART/ New York University Biotechnology Award Lecture for Basic Biotechnology, New York University School of Medicine;
Howard Taylor Ricketts Award Lecture, University of Chicago;
2013 Chicago Symposium on Translational Neuroscience: Protein Misfolding in Neurodegenerative Disease: From Basic to Translational, University of Chicago;
Keynote Lecture, 8th Protein Kinases In Drug Discovery, Boston;
27th Symposium of the Protein Society;
Plenary lecture, 11th International Conference on Advancing the Chemical Sciences;
Molecular Genetics Journal Club, Brandeis University;
5TH Annual Tufts Neuroscience Symposium, Tufts University;
ADVANCE lecture, University of Maryland Baltimore County;
Barton Child Lecture, Johns Hopkins School of Medicine;
Norman Heatley Lecture, Dunn School of Pathology, Oxford;
Lily Lecture, Lily Research Laboratories


Plenary Lecture, Norwegian Biochemical Society;
Linné Lecture, Uppsala University;
Rosalind Franklin Lecture, King’s College, London;
Keynote Address, Keystone Symposium Stockholm, Sweden;
Keynote Lecture, Life Science Institute Symposium, University of Michigan;
Chemical Methodology and Library Development Symposium, Boston University;
Keynote Lecture, Human Proteome Organization, Boston;
Frontier Symposium, American Society for Cell Biology Annual Meeting, San Francisco, CA


Industry Appointments


Member Johnson & Johnson Board of Directors,
Chair Committee on Science, Technology, and Sustainability
Member, Regulatory Compliance and Public Affairs Committee


Co-Founder, FoldRx; Director 2003-2006; 
Advisor 2007


Selected Service to the Science Community

Representative Service on Boards and Committees

Scientific Advisory Board, Brigham and Women’s Hospital, Boston, MA, 2014 - present

Stanley Center Operating Committee, Broad Institute, Cambridge, MA, 2013 - present

Chair, Science, Technology & Sustainability Committee, Johnson & Johnson, 2012- present

Inaugurated Whitehead Institute, Girls Guide to Science Program, 2010 - present

Member, Scientific Advisory Board, IMBA, 2007-2012

Chair, Richard Lounsbery Award Selection Committee, 2011

Member, Science Advisory Council, The MacArthur Foundation, 2007-2010

Member, Scientific Review Board, Chicago Biomedical Consortium, 2006-2010

Member, Scientific Advisory Board, MIT Computational & Systems Biology Institute, 2002–2007

Member, Scientific Advisory Board, Stowers Institute for Medical Research, 2000–2010

Member, Scientific Advisory Committee, Massachusetts General Hospital, 2003–2006

Member, Board of Trustees, Cold Spring Harbor Laboratory’s, 2002-2005

Member, Scientific Advisory Board, Arryx, Inc., 2001–2005

Member, Scientific Advisory Board, Radcliffe Institute for Advanced Study, Harvard, 2002, 2004

Member, Health Science Partnership Advisory Board, Boston Museum of Science, 2002–2003

Member, American Society of Cell Biology Council, 2001–2002

Member, ScienceYear Board of Advisors, Worldbook Encyclopedia, 2001–2002

Member, Government-University-Industry Research Roundtable of the National Academy of Sciences, National Academy of Engineering & the Institute of Medicine. 2000–2002 

Member, American Academy of Arts & Sciences, Midwest Council, 1998–2002

Member, Scientific Advisory Board, Neogenesis, 1998–2001

Secretary, Genetics Society of America, 1998-2000

Member, American Society for Cell Biology, Resource Bureau, 1998–present

Board of Directors, Genetics Society of America, 1995-1998

Commentary, Communication and Public Affairs


“World Changing Ideas” interview with BBC


Celebration of Science, “ The Protein Folding Problem” NIH Day, Bethesda, MD;
Whitehead Institute High School Teacher Program: “ Can Simple Cells Model Complex Neurodegenerative Diseases?”;
Whitehead Institute public outreach, “Alzheimer's and Parkinson's Disease: A Revolutionary New Point of Attack”, New York.


Whitehead Institute BOA Colloquium “Alzheimer's Disease: A Revolutionary New Point of Attack”;
Futures in Biotech 77: “How The Environment And A Single Protein Influence Evolution”;
"Using Simple Cells to Attack Complex Diseases" in Leaders in Science and Engineering: The Women of MIT, A MIT150 Symposium;
“Heat Shock Proteins and Their Implications” in Paradigm Shifts: From Biology to Technology to Medical Applications: Conquering Cancer through the Convergence of Science and Engineering Symposium - A MIT150 Symposium;
Featured in MIT Museum 150 years outstanding achievements at MIT


Futures in Biotech 57: “Mechanisms of Non-Mendelian Inheritance In Evolution”


MIT TechTV Documentaries on Parkinson’s Disease Research;
“Perspectives from the NIH 2009 Pittman Lecturer,” Perspectives on Women in Science, NIH, Bethesda MD


Presented “New Clues to Parkinson’s Disease from an Unlikely Source” to Congressional Biomedical Research Caucus, Washington, DC;
American Society for Cell Biology iBioSeminars Lectures, “The Surprising World of Prion Biology”;
MIT Technology Review, Women & Innovation panel


Harvard University Women in Science Panel Discussion, Cambridge MA;
Organized and/or participated in biology sessions at the Davos World Economic Forum 2007: Stem Cells, The Fight against Cancer, Simple Solutions to Complex Problems, and Genetic Screening Seeing the Future;
Museum of Science, The House that Darwin Built, Boston MA


Inaugurated Futures in Biotech Podcast on TWiT Network (#1 science podcast in its first week; downloaded over 37,000 times);
Featured by Massachusetts Society for Medical Research in What a Year!;
British-North American Committee;
Free University the Netherlands, FEBS Working Group on Women in Science (WISE);
Rockefeller University, Women & Science


Johnson & Johnson, Women in Leadership Anniversary Conference


Chosen as one of six MIT Professors to have their work highlighted in an internet video documentary “High-Throughput Drug Discovery” www.uplandproductions.com ;
Trinity University, Public Lecture & Distinguished Scientist Lecture;
BioIT World Conference, Keynote Speaker;
Bristol-Myers Squibb, Women in Science & Technology at BMS;
Brigham & Women’s Hospital, Lecture for Partners Office for Women’s Careers at BWH


Whitehead Partner High School Teachers Program Lectures, communicating the newest concepts in biology, Cambridge MA


MIT Independent Activities Period Forums: Advancing the Careers of Women in Science, & Balancing Career and Family, Cambridge MA 


Lectures to Biology students, Brookline High School, Brookline MA


Museum of Science, Celebrating DNA 50 Years, Boston MA;
AP Biology Faculty Lecture for teachers & students from greater Boston area high schools;
MIT Sloan School Management Conference, Driving Innovation Through Technology;
Woods Hole, Friday Evening Lectures, Televised on FCTV 13;
Gladstone Institute, lectures to general scientific community & roundtable with postdocs


MIT Knights Fellows Program, Science Bootcamp for journalists, Cambridge MA


Museum of Science, Women in Science Lecture, Boston MA


Yearly Whitehead Press Seminars aimed at educating journalists on key advances in biological sciences & medicine, from evolution to human disease, Cambridge MA


Lindquist S, Strong Unity, Rich Diversity: The Human Genome.  September 2000.  The HHMI Bulletin. 1: 14-15. Modified from The University of Chicago convocation address 


Consultant and principal in "Lights Breaking", a film on recombinant DNA technology, which received the Gold Medal for best short science film at the San Francisco Film Festival and the Silver Medal for Best Short Science Film at the New York Film Festival


Consultant to the Museum of Science and Industry, Chicago, for exhibits on cell biology and genetics

Meetings Organized
Co-Organizer, Protein- Folding Diseases: Models & Mechanisms Symposium (with Vivian Siegel), Sponsored by Disease Models & Mechanisms, The Broad Institute, 2012.
Co- Chair (with Jeffery Kelly), Keystone Symposium on Protein Misfolding Diseases: Mechanisms of Misfolding, Pathology & Therapeutic Strategies, Breckenridge, Colorado, 2006.
Chair, Whitehead Institute Annual Symposium: Biological Challenges to Humanity: Emerging & Re-Emerging Pathogens, 2002.
Co-Organizer (with Helen Blau, Rudolf Jaenisch & Harvey Lodish) Catherine A. Stratton Lectures on Critical Issues, sponsored by the MIT Women’s League, 2002.
Co-Organizer (with Steven Henikoff) National Academy of Sciences, Arthur M. Sackler Symposium: Self-Perpetuating Structural States in Biology, Disease & Genetics, 2002.
Co-Organizer (with Didier Picard & Johannes Buchner) 1st International Conference on The Hsp90 Chaperone Machine, Arolla, Switzerland, 2002.
Co-Organizer (with Susan Marqusee & Greg Petsko), Protein Society Annual Meeting, Philadelphia, Pennsylvania, 2001.
Co-Chair & organizer (with Paul Fraser), FASEB Symposium on Amyloid Proteins, Copper Mountain, Colorado, 2000.
Co-Chair & organizer (with Art Horwich & Carol Gross), Heat Shock Proteins & Molecular Chaperones, sponsored by Cold Spring Harbor Laboratories, 1998.
Co-Chair & organizer, (with Ralph Isberg) Gordon Conference on Biological Regulatory Mechanisms, Plymouth, New Hampshire, 1996.
Co-Organizer, Heat Shock Proteins & Stress Responses (with Costa Georgopolous & Rick Morimoto), Sponsored by Cold Spring Harbor Laboratories, 1994 & 1996.
Co-Organizer, Rinshoken International Conference on Heat Shock Proteins & Chaperones (with I. Yahara, K. Nagata, & R. Morimoto), Chiba, Japan, 1995.
Co-Organizer, International Symposium on the Function & Regulation of Heat Shock Proteins & Molecular Chaperones (with I. Yahara & K. Nagata), Sponsored by Kyoto University, 1993.
Co-Chair & organizer, Heat Shock Proteins International Symposium (with Bruno Maresca),  Sponsored by the Instituti Genetica i Biophysica, Ravello, Italy, 1990. 
Program Chair,  Annual Meeting of the Genetics Society of America & the Genetics Society of Canada, San Francisco, California, 1990. 
Co-Chair & organizer, UCLA Symposium on Heat Shock Proteins, Keystone, Colorado (with M. L. Pardue & J. Feramisco), 1988.
Co-Chair & organizer, Gordon Conference on Biological Regulatory Mechanisms, Plymouth, New Hampshire (with Nigel Grindley), 1985.
Founded and organized the first three meetings of the Midwest Drosophila Conference, Monticello, Illinois, 1982, 1983, & 1984.  Meetings have continued on a yearly basis since. 
Founded & Co-organized the first two meetings of the Chicago Molecular Biology Symposium, Chicago, Illinois, 1980 & 1981. 

Editorial Boards and Professional Societies

Advisory Editorial Board:  EMBO reports, 2009-present.
Editorial Board:  Disease Models and Mechanisms, 2008-present.
Editorial Board:  Public Library of Science, 2003-present.
Editorial Academy: Int. Journal of Molecular Medicine, 1998-present.
Editorial Board:  Molecular Biology of the Cell, 1996-2001.
Editorial Board: Current Biology, 1996-2003.
Editorial Board: Cell Stress and Chaperones, 1995-present. 
Editorial Board: Gene Expression, 1994-present.
Editorial Board: Molecular and Cellular Biology, 1984-2000. 
Monitoring Editor: Journal of Cell Biology, 1993-1998.
Associate Editor:  The New Biologist, 1991-1993. 

American Chemical Society
American Society for Biochemistry and Molecular Biology
American Society for Cell Biology
American Society for Microbiology
American Society of Plant Biologists
American Association for the Advancement of Science
Federation of American Scientists for Experimental Biology
Genetics Society of America
Molecular Medicine Society
Cell Stress and Chaperone Society

Grants and Sponsored Programs
Ad Hoc reviews for:  The National Science Foundation, The National Institutes of Health, The Department of Energy, The Department of Agriculture, The March of Dimes Foundation, Human Frontiers in Science Program, The Wellcome Fund, The Keck Foundation, Hereditary Disease Foundation, Burroughs Wellcome Foundation.
Harvard Molecules, Cells & Organisms (MCO) Interdisciplinary Training Program Review, 2010.
Argonne National Laboratories, Mechanistic Biology and Biotechnology Review Committee, 98-00.
Helen Hay Whitney Postdoctoral Fellowship Review Committee & Scientific Advisory Board, 97-02.
Member, Biomedical Sciences Study Section, Subcommittee 3, National Institutes of Health.
Member, Site visit team for the MacArthur Foundation Program for Parasite Biology, 88-89.
Member, Special Study Section for Project Center Grants: Stressers, Responders & the Cellular Basis
of Disease, National Institutes of Health, 1983.
Member, Genetic Basis of Disease Study Section, National Institutes of Health, 1982.


Peer-Reviewed Research 

1.    Mann PA, McLellan CA, Koseoglu S, Qian S, Kuzmin E, Flattery A, Harris G, Sher X, Murgolo N, Wang H, Devito K, Depedro N, Genilloud O, Kahn JN, Jiang B, Costanzo M, Boone C, Garlisi C, Lindquist S, Roemer T, 2014. Chemical genomics-based antifungal drug discovery: targeting glycosylphosphatidylinositol (GPI) precursor biosynthesis. ACS Inf Dis, in the press. 

2.    Whitesell L, Santagata S, Mendillo M, Lin NU, Proia DA, Lindquist S, 2014. Heat shock protein 90 (HSP90) empowers evolution of resistance to hormonal therapy in breast cancer cells. Proc Natl Acad Sci, 111(51): 18297–18302. 

3.    Reymer A, Frederick KK, Rocha S, Beke-Somfai T, Lindquist S, Nordén B, 2014. Orientation of aromatic residues in amyloid cores: structural insights into prion fiber diversity. Proc Natl Acad Sci, 111 (48): 17158-17163.

4.    Jarosz DF, Lancaster AK, Brown JCS, Lindquist S, 2014. An evolutionarily conserved prion-like element converts wild fungi from metabolic specialists to generalists. Cell, 158, 1072–1082.
5.    Jarosz DF, Brown JCS, Walker GA, Datta MS, Ung WL, Lancaster AK, Chang A, Newby GA, Weitz DA, Bisson LF, Lindquist S, 2014. Cross-kingdom chemical communication drives a heritable, mutually beneficial prion-based transformation of metabolism. Cell, 158, 1083–1093.

6.    Caraveo G, Auluck PK, Whitesell L, Chung CY, Baru V, Mosharov EV, Yan X, Johny MB, Soste M, Picotti P, Kim H, Caldwell KA, Caldwell GA, Sulzer D, Yue DT, Lindquist S, 2014. Calcineurin determines toxic versus beneficial responses to α-synuclein. Proc Natl Acad Sci, doi:10.1073/pnas.1413201111. PMCID: PMC4151770

7.    Kayatekin C, Matlack KES, Hesse WR, Guan Y, Chakrabortee S, Russ J, Wanker EE, Shah JV, Lindquist S, 2014. Prion-like proteins sequester and suppress the toxicity of huntingtin exon 1. Proc Natl Acad Sci, 111(33): 12085-90. PMCID: PMC4143035

8.    Lancaster AK, Nutter-Upham A, Lindquist S, King OD, 2014. PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition. Bioinformatics, 30 (17): 2501-2502. PMCID: PMC4147883

9.    Scherz-Shouval R, Santagata S, Mendillo M, Sholl LM, Ben-Aharon I, Beck AH, Dias-Santagata D, Koeva M, Stemmer SM, Whitesell L, Lindquist S, 2014. The reprogramming of tumor stroma by HSF1 is a potent enabler of malignancy. Cell, 158(3): 564–578. PMCID: PMC4249939

10.    Taipale M, Tucker G, Peng J, Krykbaeva I, Lin ZY, Larsen B, Choi H, Berger B, Gingras AC, Lindquist S, 2014. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. Cell, 158: 434-448.
11.    Shalgi R, Hurt JA, Lindquist S, Burge CB, 2014. Widespread inhibition of post-transcriptional splicing shapes the cellular transcriptome following heat shock. Cell Reports, 7:1362-1370. 

12.    Wijeratne EMK, Xu Y-M, Scherz-Shouval R, Marron MT, Rocha DD, Liu MX, Lotufo LVC, Santagata S, Lindquist S, Whitesell L, Gunatilaka, AAL, 2014. Structure-activity relationships for Withanolides as inducers of the cellular heat-shock response. J Med Chem, 57 (7): 2851–2863.

13.    Petschnigg J, Groisman B, Kotlyar M, Taipale M, Zheng Y, Kurat C, Sayad A, Sierra JR, Usaj MM, Snider J, Nachman A, Krykbaeva I, Tsao M-S, Moffat J, Pawson T, Lindquist S, Jurisica I, Stagljar, I, 2014. Mammalian-Membrane-Two-Hybrid (MaMTH): a novel split-ubiquitin assay for investigation of signaling pathways in human cells. Nat Meth, 11(5): 585-592.

14.    Matlack KES, Tardiff DF, Narayan P, Hamamichi S, Caldwell KA, Caldwell GA, and Lindquist S, 2014. Clioquinol promotes the degradation of metal-dependent amyloid- (A) oligomers to restore endocytosis and ameliorate Atoxicity. Proc Natl Acad Sci, 111 (11): 4013-4018. PMCID: PMC3964050 

15.    Frederick KK, Debelouchina GT, Kayatekin C, Dorminy T, Jacavone AC, Griffin RG and Lindquist S, Distinct prion strains are defined by amyloid core structure and chaperone binding site dynamics. Chem Biol, 21(2): 295-305. PMCID: PMC4030713

16.    Valastyan JS, Termine DJ and Lindquist S, 2014. Splice isoform and pharmacological studies reveal that sterol depletion relocalizes α-synuclein and enhances its toxicity. Proc Natl Acad Sci, 111(8): 3014-3019. PMCID: PMC3939903

17.    Tardiff DF, Jui NT, Khurana V, Tambe MA, Thompson ML, Chung CY, Kamadurai HB, Kim HT, Lancaster AK, Caldwell KA, Caldwell GA, Rochet J-C, Buchwald SL and Lindquist S, 2013. Yeast Reveal a “Druggable” Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons. Science, 342(6161): 979-983. PMCID: PMC3993916

18.    Chung CY, Khurana V, Auluck PK, Tardiff DF, Mazzulli JR, Soldner F, Baru V, Lou Y, Freyzon Y, Cho S, Mungenast AE, Muffat J, Mitalipova M, Pluth MD, Jui, NT, Schule B, Lippard SJ, Tsai L-H, Krainc D, Buchwald SL, Jaenisch R and Lindquist S, 2013. Identification and rescue of α-synuclein toxicity in Parkinson patient–derived neurons. Science, 342(6161): 983-987.  PMCID: PMC4022187

19.    Rohner N, Jarosz DF, Kowalko JE, Yoshizawa M, Jeffery WR, Borowsky RL, Lindquist S, Tabin CJ, 2013. Cryptic variation in morphological evolution: HSP90 as a capacitor for loss of eyes in cavefish. Science, 342(6164): 1372-1375. PMCID: PMC4004346

20.    Lambert JP, Ivosev G, Couzens AL, Larsen B, Taipale M, Lin ZY, Zhong Q, Lindquist S, Vidal M, Aebersold R, Pawson T, Bonner R, Tate S, Gingras AC, 2013. Rapid identification of differential interactomes by affinity purification coupled with data independent mass spectrometry acquisition. Nat Meth, 10(12): 1239-1245.

21.    Jackson WS, Borkowski AW, Watson NE, King OD, Faas H, Jasanoff A, Lindquist S, 2013. Profoundly different prion diseases in knock-in mice carrying single PrP codon substitutions associated with human diseases. Proc Natl Acad Sci, 110(36):14759-14764. PMCID: PMC3767526

22.    Santagata S, Mendillo ML, Tang Y, Subramanian A, Perley CC, Roche SP, Wong B, Narayan R, Kwon H, Koeva M, Amon A, Golub TR, Porco JA Jr, Whitesell L, Lindquist S, 2013. Tight coordination of protein translation and heat shock factor 1 activation supports the anabolic malignant state. Science, 341:doi:10.1126/science.1238303. PMCID: PMC3959726.

23.    Vincent BM, Lancaster AK, Scherz-Shouval R, Whitesell L, Lindquist S, 2013. Fitness trade-offs restrict the evolution of resistance to Amphotericin B. PLoS Biol, 11(10): e1001692. doi:10.1371/journal.pbio.1001692. PMCID: PMC3812114

24.    Taipale M, Krykbaeva I, Whitesell L, Santagata S, Zhang J, Liu Q, Gray NS, Lindquist S, 2013. Chaperones as thermodynamic sensors of drug::target interactions in living cells. Nat Biotech, 31(7): 630-637. PMCID: PMC3774174

25.    Holmes DL, Lancaster AK, Lindquist S, Halfmann R, 2013. Heritable remodeling of yeast multicellularity by an environmentally responsive prion. Cell, 153(1): 153-165. PMCID: PMC3759520

26.    Shalgi R, Hurt JA, Krykbaeva I, Taipale M, Lindquist S, Burge CB, 2012. Widespread regulation of translation by elongation pausing in heat shock. Mol Cell 49(3): 439-452.

27.    Muralidharan V, Oksman A, Pal P, Lindquist S, Goldberg DE, 2012. Plasmodium falciparum heat shock protein 110 stabilizes the asparagine repeat-rich parasite proteome during malarial fevers. Nat Commun 3:1310.

28.    Dai C, Santagata S, Tang Z, Shi J, Cao J, Kwon H, Bronson RT, Whitesell L, Lindquist S, 2012. Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis. J Clin Invest 122(10):3742-3754. PMCID: PMC3461912

29.    Saibil, HR, Seybert A, Habermann A, Winkler J, Eltsov M, Perkovic M, Castaño-Diez D, Scheffer MP, Haselmann U, Chlanda P, Lindquist S, Tyedmers J, Frangakis AS, 2012.  Heritable yeast prions have a highly organized 3-dimensional architecture with inter-fiber structures.  Proc Natl Acad Sci 109(37): 14906-14911.

30.    Taipale M, Krykbaeva I, Koeva M, Kayatekin C, Westover KD, Karras GI, Lindquist S, 2012.  Quantitative analysis of hsp90-client interactions reveals principles of substrate recognition.  Cell 150(5): 987-1001. PMID: 22939624

31.    Mendillo ML, Santagata S, Koeva M, Bell G, Hu R, Tamimi RM, Fraenkel E, Ince TA, Whitesell L, Lindquist S, 2012.  HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers.  Cell 150(3): 549–562. PMCID: PMC3438889

32.    Krishnan R, Goodman JL, Mukhopadhyay S, Pacheco CD, Lemke EA, Deniz AA, Lindquist S, 2012. Conserved features of intermediates in amyloid assembly determine their benign or toxic states. Proc Natl Acad Sci 109(28): 11172-11177.

33.    McLellan CA, Whitesell L, King OD, Lancaster AK, Mazitschek R, Lindquist S, 2012. Inhibiting GPI anchor biosynthesis in fungi stresses the endoplasmic reticulum and enhances immunogenicity. ACS Chem Biol 7(9):1520-1528. PMID: 22724584

34.    Halfmann R, Wright JR, Simon Alberti S, Lindquist S, Rexach M, 2012. Prion formation by a yeast GLFG nucleoporin. Prion 6(4): 391-399. PMCID: PMC3609069

35.    Treusch S, Lindquist S, 2012.  An intrinsically disordered yeast prion arrests the cell cycle by sequestering a spindle pole body component.  J Cell Biol 197(3): 369-79. PMCID: PMC3341155

36.    Youngsaye W, Dockendorff C, Vincent B, Hartland CL, Bittker JA, Dandapani S, Palmer M, Whitesell L, Lindquist S, Schreiber SL, Munoz B, 2012. Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles.  Bioorg Med Chem Lett 22(9): 3362-5. PMCID: PMC3386803

37.    Halfmann R, Jarosz DF, Jones SK, Chang A, Lancaster AK, Lindquist S, 2012.  Prions are a common mechanism for phenotypic inheritance in wild yeasts. Nature 482 (7385): 363-368. PMCID: PMC3319070

38.    Tardiff DF, Tucci ML, Caldwell KA, Caldwell GA, Lindquist S, 2012.  Different 8-hydroxyquinolines Protect Models of TDP-43, α-synuclein, and Polyglutamine Proteotoxicity through Distinct Mechanisms.  J Biol Chem 287(6): 4107-4120. PMCID: PMC3281691

39.    Santagata S, Xu Y, Wijeratne EMK, Kontnik R, Rooney C, Perley CC, Kwon H, Clardy J, Kesari S, Whitesell L, Lindquist S, Gunatilaka AAL, 2012.  Using the heat-shock response to discover anticancer ompounds that target protein homeostasis. ACS Chem Biol 7(2): 340-9. PMCID: PMC3291478

40.    Donmez G, Arun A, Chung CY, McLean P, Lindquist S, Guarente L, 2012.  SIRT1 protects against α-synuclein aggregation by activating molecular chaperones.  J Neurosci 32(1): 124-32.

41.    Bryan AW Jr, O’Donnell CW, Menke M, Cowen LJ, Lindquist S, Berger, B, 2012. STITCHER: Dynamic assembly of likely amyloid and prion beta-structures from secondary structure predictions. Proteins 80(2): 410-420.

42.    Santagata S, Hu R, Lin NU, Mendillo ML, Collins LC, Hankinson SE, Schnitt SJ, Whitesell L, Tamimi RM, Lindquist S, Ince TA, 2011.  High levels of nuclear HSF1 are associated with poor prognosis in breast cancer.  Proc Natl Acad Sci USA 108(45): 18378-83. PMCID: PMC3215027

43.    Treusch S, Hamamichi S, Goodman JL, Matlack KES, Chung CY, Baru V, Shulman JM, Parrado A, Bevis BJ, Valastyan JS, Han H, Lindhagen-Persson M, Reiman EM, Evans DA, Bennett DA, Olofsson A, DeJager PL, Tanzi RE, Caldwell KA, Caldwell GA, Lindquist S, 2011. Functional links between Aβ toxicity, endocytic trafficking and Alzheimer’s Disease risk factors in yeast.  Science 334(6060): 1241-5. PMCID: PMC3281757.

44.    Valastyan JS, Lindquist S, 2011.  TorsinA and the torsinA-interacting protein printor have no impact on endoplasmic reticulum stress or protein trafficking in yeast.  PLoS ONE 6(7): e22744. PMCID: PMC3144245

45.    Soldner F, Laganière J, Cheng AW, Hockemeyer D, Gao Q, Alagappan R, Khurana V, Golbe LI, Myers RH, Lindquist S, Zhang L, Guschin D, Fong LK, Vu BJ, Meng X, Urnov FD, Rebar EJ, Gregory PD, Zhang HS, Jaenisch R, 2011. Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations. Cell 146(2): 318-31.

46.    Castro CE, Dong J, Boyce MC, Lindquist S, Lang MJ, 2011. Physical properties of polymorphic yeast prion amyloid fibers. Biophys J 101(2): 439-48.

47.    Youngsaye W, Vincent B, Hartland CL, Morgan BJ, Buhrlage SJ, Johnston S, Bittker JA, MacPherson L, Dandapani S, Palmer M, Whitesell L, Lindquist S, Schreiber SL, Munoz B, 2011. Piperazinyl quinolines as chemosensitizers to increase fluconazole susceptibility of Candida albicans clinical isolates. Bioorg Med Chem Lett, 21(18): 5502-5. PMCID: PMC3287054

48.    Halfmann R, Alberti S, Krishnan R, Lyle N, O’Donnell CW, King OD, Berger B, Pappu RV, Lindquist S, 2011. Opposing effects of glutamine and asparagine govern prion formation by intrinsically disordered proteins. Mol Cell 43: 72-84. PMCID: PMC3132398

49.    O’Donnell CW, Waldispühl J, Lis M, Halfmann R, Devadas S, Lindquist S, Berger B, 2011. A method for probing the mutational landscape of amyloid structure. Bioinformatics 27: I34-I42. 
    PMCID: PMC3117379

50.    Lan A, Smoly I, Rapaport G, Lindquist S, Fraenkel E, Yeger-Lotem E. ResponseNet: Revealing signaling and regulatory networks linking genetic and transcriptomic screening data, 2011. Nuc Acids Res 39(Web Server issue): W424-9.

51.    Manogaran AL, Hong JY, Hufana J, Tyedmers J, Lindquist S, Liebman SW, 2011. Prion formation and polyglutamine aggregation are controlled by two classes of genes. PLoS Genet 7(5): e1001386.

52.    Resenberger UK, Harmeier A, Woerner AC, Goodman JL, Müller V, Krishnan R, Vabulas RM, Kretzschmar HA, Lindquist S, Hartl FU, Multhaup G, Winklhofer KF, Tatzelt J, 2011. The cellular prion protein mediates neurotoxic signaling of β-sheet-rich conformers independent of prion replication. EMBO J 30: 2057-70.

53.    Ju S, Tardiff DF, Han H, Divya K, Zhong Q, Maquat LE, Bosco DA, Hayward LJ, Brown Jr. RH, Lindquist S, Ringe D, Petsko GA, 2011. A yeast model for FUS/TLS-dependent cytotoxicity. PLoS Biol 9(4): e1001052.

54.    Heinrich SU, Lindquist S, 2011. Protein-only mechanism induces self-perpetuating changes in the activity of neuronal Aplysia cytoplasmic polyadenylation element binding protein (CPEB). Proc Natl Acad Sci USA 108: 2999-3004. PMCID: PMC3041084

55.    Dumitriu A, Pacheco CD, Wilk JB, Strathearn KE, Latourelle JC, Goldwurm S, Pezzoli G, Rochet J-C, Lindquist S, Myers RH, 2011. Cyclin-G associated Kinase Modifies α-Synuclein Expression and Toxicity in Parkinson’s disease: Results from the GenePD Study. Hum Mol Genet 20: 1478-87.

56.    Jarosz DF, Lindquist S, 2010. Hsp90 and environmental stress transform the adaptive value of natural genetic variation. Science 330: 1820-4. PMCID: PMC3260023

57.    Dong J, Castro CE, Boyce MC, Lang MJ, Lindquist S, 2010. Optical Trapping with High Forces Reveals Unexpected Behaviors of Prion Fibrils. Nat Struct Mol Biol 17: 1422-30.

58.    Lewandowski NM, Ju S, Verbitsky M, Ross B, Geddie ML, Rockenstein E, Adame A, Muhammad A, Vonsattel JP, Ringe D, Cote L, Lindquist S, Masliah E, Petsko GA, Marder K, Clark LN, Small SA, 2010. Polyamine pathway contributes to the pathogenesis of Parkinson disease. Proc Natl Acad Sci USA 107: 16970-5.

59.    Garrity SJ, Sivanathan V, Dong J, Lindquist S, Hochschild A, 2010. Conversion of a yeast prion protein to an infectious form in bacteria. Proc Natl Acad Sci USA 107: 10596-601. 

60.    Tyedmers J, Treusch S, Dong J, McCaffery JM, Bevis B, Lindquist S, 2010. Prion induction involves an ancient system for the sequestration of aggregated proteins and heritable changes in prion fragmentation. Proc Natl Acad Sci USA 107: 8633-8. PMCID: PMC2889312

61.    Su LJ, Auluck PK, Outeiro TF, Yeger-Lotem E, Kritzer JA, Tardiff DF, Strathearn KE, Liu F, Cao S, Hamamichi S, Hill KJ, Caldwell KA, Bell GW, Fraenkel E, Cooper AA, Caldwell GA, McCaffery JM, Rochet J-C, Lindquist S, 2010.  Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson disease models. Dis Model Mech 3: 194-208.

62.    Faas H, Jackson WS, Borkowski AW, Wang X, Ma J, Lindquist S, Jasanoff A, 2010.  Context-dependent perturbation of neural systems in transgenic mice expressing a cytosolic prion protein. Neuroimage 49: 2607-17.

63.    Steele AD, Zhou Z, Jackson WS, Zhu C, Auluck P, Moskowitz MA, Chesselet MF, Lindquist S, 2009.  Context dependent neuroprotective properties of prion protein (PrP). Prion 3: 240-9. 

64.    Brown JCS, Lindquist S, 2009.  A heritable switch in carbon source utilization driven by an unusual yeast prion. Genes Dev 23: 2320-32. 

65.    Jackson WS, Borkowski A, Faas H, Steele A, King O, Watson N, Jasanoff A, Lindquist S, 2009.  Spontaneous generation of prion infectivity in fatal familial insomnia knock-in mice.  Neuron 6: 438-450. 

66.    Sénéchal P, Arseneault G, Leroux A, Lindquist S, Rokeach LA, 2009. The Schizosaccharomyces pombe Hsp104 disaggregase is unable to propagate the [PSI+] prion. PLoS ONE 4: e6939. 

67.    Kritzer JA, Hamamichi S, McCaffery JM, Santagata S, Naumann TA, Caldwell KA, Caldwell GA, Lindquist S, 2009.  Rapid Selection of Cyclic Peptides that Reduce Alpha-Synuclein Toxicity in Yeast and Animal Models. Nat Chem Biol 5: 655-63. 

68.    Wacker JL, Huang S-Y, Steele AD, Aron R, Lotz GP, Nguyen QV, Giorgini F, Roberson ED, Lindquist S, Masliah E, Muchowski PJ, 2009.  Loss of Hsp70 Exacerbates Pathogenesis But Not Levels of Fibrillar Aggregates in a Mouse Model of Huntington’s Disease. J Neurosci 29: 9104-14. 

69.    Wendler P, Shorter J, Snead D, Plisson C, Clare DK, Lindquist S, Saibil HR, 2009. Motor mechanism for protein threading through Hsp104. Mol Cell 34: 81-92. 

70.    Beauregard PB, Guérin R, Turcotte C, Lindquist S, Rokeach LA, 2009. A nucleolar protein allows viability in the absence of the essential ER chaperone calnexin. J Cell Sci 122: 1342-1351.

71.    Alberti S, Halfmann R, King O, Kapila A, Lindquist S, 2009.  A systematic survey identifies prions and illuminates sequence features of prionogenic proteins. Cell 137: 146-158. PMCID: PMC2683788

72.    Bryan, AW, Menke M, Cowen LJ, Lindquist S, Berger B, 2009.  BETASCAN:  Probable amyloids identified by pairwise probabilistic analysis.  PLoS Comp Biol 5: e1000333. 

73.    Yeger-Lotem E, Riva L, Su LJ, Gitler AD, Cashikar A, King OD, Auluck PK, Geddie ML, Valastyan JS, Karger DR, Lindquist S, Fraenkel E, 2009. Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity. Nat Genet 41: 316-23. PMCID: PMC2733244

74.    Gitler AD, Chesi A, Geddie ML, Strathearn KE, Hamamichi S, Hill KJ, Caldwell KA, Caldwell GA, Cooper AA, Rochet J-C, Lindquist S, 2009. -Synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity. Nat Genet 41: 308-15.

75.    Cowen LE, Singh SD, Köhler JR, Collins C, Zaas A, Schell W, Aziz H, Mylonakis E, Perfect JR, Whitesell L, Lindquist S, 2009.  Harnessing Hsp90 Function as a Novel Therapeutic Strategy for Fungal Infectious Disease. Proc Natl Acad Sci USA 106: 2818-23. PMCID: PMC2650349  

76.    Rappley I, Gitler AD, Selvy PE, LaVoie MJ, Levy BD, Brown HA, Lindquist S, Selkoe DJ, 2009.  Evidence that alpha-synuclein does not inhibit phospholipase D. Biochemistry 48: 1077-83.

77.    Heikenwalder M, Kurrer MO, Margalith I, Kranich J, Zeller N, Haybaeck J, Polymenidou M, Matter M, Bremer J, Jackson WS, Lindquist S, Sigurdson CJ, Aguzzi A, 2008.  Lymphotoxin-dependent prion replication in inflammatory stromal cells of granulomas. Immunity 29: 998-1008.

78.    Tyedmers J, Madariaga ML, Lindquist S, 2008. Prion Switching in Response to Environmental Stress. PLoS Biol 6: e294. 

79.    Duennwald ML, Lindquist S, 2008. Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity. Genes Dev 22: 3308-19. 

80.    Shorter J, Lindquist S, 2008.  Hsp104, Hsp70 and Hsp40 interplay regulates formation, growth and elimination of Sup35 prions. EMBO J 27: 2712-24. 

81.    Steele AD, Hutter G, Jackson WS, Heppner FL, Borkowski AW, King OD, Raymond G, Aguzzi A, Lindquist S, 2008. Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease. Proc Natl Acad Sci USA 105: 13626-31. 

82.    Lo Bianco C, Shorter J, Régulier E, Lashuel H, Iwatsubo T, Lindquist S, Aebischer P, 2008. Hsp104 Antagonizes α-Synuclein Aggregation and Reduces Dopaminergic Degeneration in a Rat Model of Parkinson’s Disease. J Clin Invest 118: 3087-97. 

83.    Chen D, Steele AD, Hutter G, Bruno J, Govindarajan A, Easlon E, Lin S-J, Aguzzi A, Lindquist S, Guarente L, 2008. The role of calorie restriction and SIRT1 in prion mediated neurodegeneration. Exp Gerontol 43: 1086-93.

84.    Halfmann R, Lindquist S, 2008. Screening for Amyloid Aggregation by Semi-Denaturing Detergent-Agarose Gel Electrophoresis. J Visualized Experiments 17: 7/16/2008, doi: 10.3791/838.  

85.    Wang H, Duennwald ML, Roberts BE, Rozeboom LM, Zhang YL, Steele AD, Krishnan R, Su LJ, Griffin D, Mukhopadhyay S, Hennessy EJ, Weigele P, Blanchard BJ, King J, Deniz AA, Buchwald SL, Ingram VM, Lindquist S, Shorter J, 2008. Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs. Proc Natl Acad Sci USA 105: 7159-64. 

86.    Douglas PM, Treusch S, Ren H-Y, Halfmann R, Duennwald ML, Lindquist S, Cyr DM, 2008. Chaperone-dependent amyloid assembly protects cells from prion toxicity. Proc Natl Acad Sci USA 105(20): 7206–11. PMCID: PMC2438228

87.    Johnson BS, McCaffery JM, Lindquist S, Gitler AD, 2008.  A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicity. Proc Natl Acad Sci USA 105: 6439-44. PMCID: PMC2359814

88.    Sadlish H, Rampelt H, Shorter J, Wegrzyn RD, Andreasson C, Lindquist S, Bukau B, 2008. Hsp110 Chaperones Regulate Prion Formation and Propagation in S. cerevisiae by Two Discrete Activities. PLoS ONE 3: e1763.  

89.    Sangster TA, Salathia N, Undurraga S, Schellenberg K, Lindquist S, Queitsch C, 2008b. HSP90 affects the expression of genetic variation and developmental stability in quantitative traits. Proc Natl Acad Sci USA 105: 2963-68.  

90.    Sangster TA, Salathia N, Lee HN, Watanabe E, Schellenberg K, Morneau K, Wang H, Undurraga S, Queitsch C, Lindquist S, 2008a. HSP90-buffered genetic variation is common in Arabidopsis thaliana. Proc Natl Acad Sci USA 105: 2969-74. 

91.    Steele AD, Hetz C, Yi CH, Jackson WS, Borkowski AW, Yuan J, Wollmann RH, Lindquist S, 2007. Prion Pathogenesis is Independent of Caspase-12. Prion 1: 1-5.  

92.    Gitler AD, Bevis BJ, Shorter J, Strathearn KE, Hamamichi S, Su LJ, Caldwell KA, Caldwell GA, Rochet JC, McCaffery JM, Barlowe C, Lindquist S, 2008. The Parkinson's disease protein {alpha}-synuclein disrupts cellular Rab homeostasis. Proc Natl Acad Sci USA 105: 145-50.

93.    Wendler P, Shorter J, Plisson C, Cashikar AG, Lindquist S, Saibil HR, 2007. Atypical AAA+ subunit packing creates an expanded cavity for disaggregation by the protein-remodeling factor Hsp104. Cell 131: 1366-77.  

94.    Hess S, Lindquist S, Scheibel T, 2007. Alternate assembly pathways of the amyloidogenic yeast prion determinant Sup35p-NM. EMBO Rep 8: 1196-201.

95.    Steele AD, King OD, Jackson WS, Hetz CA, Borkowski AW, Thielen P, Wollmann R, Lindquist S, 2007. Diminishing apoptosis by deletion of Bax or overexpression of Bcl-2 does not protect against infectious prion toxicity in vivo.  J Neurosci 27(47): 13022-27.

96.    Dong J, Bloom JD, Goncharov V, Chattopadhyay M, Millhauser GL, Lynn DG, Scheibel T, Lindquist S, 2007. Probing the role of PrP repeats in conformational conversion and amyloid assembly of chimeric yeast prions. J Biol Chem 282(47): 34204-12.

97.    Dai C, Whitesell L, Rogers AB, Lindquist S, 2007.  Heat-shock factor 1 is a powerful multifaceted modifier of carcinogenesis.  Cell 130: 1005-18.  

98.    Sangster TA, Bahrami A, Wilczek A, Watanabe E, Schellenberg K, McLellan C, Kelley A, Kong SW, Queitsch C, Lindquist S, 2007.  Phenotypic diversity and altered environmental plasticity in Arabidopsis thaliana with reduced Hsp90 levels.  PLoS ONE 2: e648.

99.    Alberti S, Gitler AD, Lindquist S, 2007. A suite of Gateway (®) cloning vectors for high-throughput genetic analysis in Saccharomyces cerevisiae. Yeast 24: 913-19.  

100.    Tessier PM, Lindquist S, 2007. Prion recognition elements govern nucleation, strain specificity and species barriers. Nature 447: 556-61.

101.    Doyle SM, Shorter J, Zolkiewski M, Hoskins JR, Lindquist S, Wickner S, 2007. Asymmetric deceleration of ClpB or Hsp104 ATPase activity unleashes protein-remodeling activity. Nat Struct Biol 14: 114-22.

102.    Mukhopadhyay S, Krishnan R, Lemke EA, Lindquist S, Deniz AA, 2007. A natively unfolded yeast prion monomer adopts an ensemble of collapsed and rapidly fluctuating structures. Proc Natl Acad Sci USA 104: 2649-54.

103.    Steele AD, Jackson WS, King OD, Lindquist S, 2007. The power of automated high-resolution behavior analysis revealed by its application to mouse models of Huntington’s and prion diseases. Proc Natl Acad Sci USA 104: 1983-88.

104.    Cowen LE, Carpenter AE, Matangkasombut O, Fink GR, Lindquist S, 2006.  Genetic Architecture of Hsp90-Dependent Drug Resistance. Eukaryot Cell 5: 2184-88.

105.    Shorter J, Lindquist S, 2006. Destruction or potentiation of different prions catalyzed by similar Hsp104 remodeling activities. Mol Cell 23: 425-38.

106.    Cooper AA, Gitler AD, Cashikar A, Haynes CM, Hill KJ, Bhullar B, Liu K, Xu K, Strathearn KE, Liu F, Cao S, Caldwell KA, Caldwell GA, Marsischky G, Kolodner RD, LaBaer J, Rochet JC, Bonini NM, Lindquist S, 2006. -Synuclein blocks ER-Golgi traffic and Rab 1 rescues neuron loss in Parkinson’s models. Science 313: 324-28.  

107.    Ehrnhoefer DE, Duennwald M, Markovic P, Engemann S, Roark M, Legleiter J, Muchowski P, Thompson LM, Lindquist S, Wanker EE, 2006. Green tea (-)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models. Hum Mol Genet 15: 2743-51.

108.    Duennwald ML, Jagadish S, Muchowski PJ, Lindquist S, 2006. Flanking sequences profoundly alter polyglutamine toxicity in yeast. Proc Natl Acad Sci USA 103(29): 11045-50.

109.    Duennwald ML, Jagadish S, Giorgini F, Muchowski PJ, Lindquist S, 2006. A network of protein interactions determines polyglutamine toxicity. Proc Natl Acad Sci USA 103(29): 11051-56.

110.    Steele AD, Emsley JG, Özdinler PH, Lindquist S, Macklis JD, 2006.  Prion protein (PrPc) positively regulates neural precursor proliferation during developmental and adult mammalian neurogenesis.  Proc Natl Acad Sci USA 10: 3416-21. 

111.    Zhang CC, Steele AD, Lindquist SL, Lodish HF, 2006. Prion protein is expressed on long-term repopulating hematopoietic stem cells and is important for their self-renewal. Proc Natl Acad Sci USA 10: 2184-89.

112.    Homann OR, Cai H, Becker JM, Lindquist SL, 2005.  Harnessing Natural Diversity to Probe Metabolic Pathways.  PLoS Genet 1: e80.

113.    Chen D, Steele AD, Lindquist S, Guarente L, 2005. Increase in activity during calorie restriction requires Sirt1. Science 310: 1641 (Brevia).

114.    Cowen LE, Lindquist S, 2005.  Hsp90 potentiates the rapid evolution of new traits:  drug resistance in diverse fungi. Science 309: 2185-89.

115.    Krishnan R, Lindquist SL, 2005. Structural insights into a yeast prion illuminate nucleation and strain diversity. Nature 435: 765-72.

116.    Cashikar AG, Duennwald M, Lindquist SL. 2005. A chaperone pathway in protein disaggregation: Hsp26 alters the nature of protein aggregates to facilitate reactivation by hsp104. J Biol Chem 280: 23869-75.

117.    Colby DW, Chu Y, Cassady J, Duennwald M, Zazulak H, Webster JM, Messer A, Lindquist S, Ingram V, Wittrup KD, 2004.  Potent inhibition of huntingtin aggregation and cytotoxicity by a disulfide bond-free single domain intrabody. Proc Natl Acad Sci USA 101:17616-21. Erratum in: Proc Natl Acad Sci USA 2005 102: 955.

118.    True H, Berlin I, Lindquist S, 2004. Epigenetic regulation of translation reveals hidden genetic variation to produce complex traits. Nature 431: 184-87.

119.    Shorter J, Lindquist S, 2004.  Hsp104 Catalyzes Formation and Elimination of Self-Replicating Sup35 Prion Conformers.  Science 304: 1793-97. 

120.    Derkatch IL, Uptain SM, Outeiro TF, Krishnan R, Lindquist SL, Liebman SW, 2004. Effects of Q/N-rich, polyQ, and non-polyQ amyloids on the de novo formation of the [PSI+] prion in yeast and aggregation of Sup35 in vitro. Proc Natl Acad Sci USA 101: 12934-39.

121.    Scheibel T, Bloom J, Lindquist SL, 2004.  The Elongation of Yeast Prion Fibers Involves Separable Steps of Association and Conversion.  Proc Natl Acad Sci USA 101: 2287-92.

122.    Schirmer EC, Homann OR, Kowal AS, Lindquist S, 2004. Dominant Gain-of-Function Mutations in Hsp104p Reveal Crucial Roles for the Middle Region. Mol Biol Cell 15: 2061-72.

123.    Si K, Lindquist S, Kandel ER, 2003. A neuronal isoform of the Aplysia CPEB has prion-like properties. Cell 115: 879-91.

124.    Outeiro TF, Lindquist S, 2003. Yeast cells provide insight into Alpha-synuclein biology and pathobiology. Science 302: 1772-75.

125.    Willingham S, Outeiro TF, DeVit MJ, Lindquist SL, Muchowski PJ, 2003. Yeast genes that enhance the toxicity of a mutant huntingtin fragment of alpha-synuclein. Science 302: 1769-72.

126.    Resende CG, Outeiro TF, Sands L, Lindquist S, Tuite MF, 2003. Prion protein gene polymorphisms in Saccharomyces cerevisiae. Mol Microbiol 49: 1005-17.

127.    Scheibel T, Parthasarathy R, Sawicki G, Lin X-M, Jaeger H, Lindquist S, 2003. Conducting nanowires built by controlled self-assembly of amyloid fibers and selective metal deposition. Proc Natl Acad Sci USA 100: 4527-32.

128.    Liu J-J, Sondheimer N, Lindquist S, 2002. Changes in the middle region of Sup35 profoundly alter the nature of epigenetic inheritance for the yeast prion [PSI+]. Proc Natl Acad Sci USA 99: 16446-53.

129.    Ma J, Lindquist S, 2002. Conversion of PrP to a Self-Perpetuating PrPSc-like Conformation in the Cytosol. Science 298: 1785-88.

130.    Ma J, Wollmann R, Lindquist S, 2002. Neurotoxicity and Neurodegeneration when PrP Accumulates in the Cytosol. Science 298: 1781-85.

131.    Queitsch C, Sangster TA, Lindquist S, 2002. Hsp90 as a capacitor of phenotypic variation. Nature 417: 618-24.

132.    Cashikar A, Schirmer E, Hattendorf D, Glover J, Ramakrishnan M, Ware D, Lindquist S, 2002.  Defining a Pathway of Communication from the C-Terminal Peptide Binding Domain to the N-Terminal ATPase Domain in the AAA Protein. Molecular Cell 9: 751-60.

133.    Hattendorf DA, Lindquist S, 2002.  Analysis of the AAA sensor-2 motif in the C-terminal ATPase domain of Hsp104 with a site-specific fluorescent probe of nucleotide binding. Proc Natl Acad Sci USA 99: 2732-37. 

134.    Hattendorf DA, Lindquist S, 2002.  Cooperative kinetics of both Hsp104 ATPase domains and interdomain communication revealed by AAA sensor-1 mutants. EMBO J  21: 12-21.

135.    Chernoff YO, Uptain SM, Lindquist SL, 2002. Analysis of Prion Factors in Yeast. Methods Enzymol 351: 499-538.

136.    Scheibel T, Lindquist S, 2001. The role of conformational flexibility in prion propagation and maintenance for Sup 35p. Nat Struct Biol 8: 958-62.

137.    Ma J, Lindquist S, 2001. Wild-type PrP and a mutant associated with prion disease are subject to retrograde transport and proteasome degradation. Proc Natl Acad Sci USA 98: 14955-60.

138.    Jensen MA, True HL, Chernoff YO, Lindquist S, 2001. Molecular Population Genetics and Evolution of a Prion-like Protein in Saccharomyces cerevisiae. Genetics 159: 527-35.

139.    Uptain S, Sawicki G, Caughey B, Lindquist S, 2001. Strains of [Psi+] are distinguished by their efficiencies of prion-mediated conformational conversion. EMBO J 20: 1-10.

140.    Sondheimer N, Lopez N, Craig EA, Lindquist S, 2001. The role of Sis1 in the maintenance of the [RNQ+] prion. EMBO J 20: 2435-42.

141.    Scheibel T, Kowal AS, Bloom JD, Lindquist SL, 2001. Bi-directional amyloid fiber growth for a yeast prion determinant. Curr Biol 11: 366-69. 

142.    Schirmer EC, Ware DM, Queitsch C, Kowal AS, Lindquist S, 2001. Subunit interactions influence the biochemical and biological properties of Hsp104. Proc Natl Acad Sci USA 98: 914-19.

143.    Clos J, Klaholz L, Kroemer M, Krobitsch S, Lindquist S, 2001. Heat shock protein 100 and the amastigote stage-specific A2 proteins of Leishmania donovani. Med Microbiol Immunol 190: 47-50.

144.    True HL, Lindquist SL, 2000. A yeast prion provides a mechanism for genetic variation and phenotypic diversity. Nature 407: 477-83.

145.    Serio TR, Cashikar AG, Kowal AS, Sawicki GJ, Moslehi JJ, Serpell L, Arnsdorf MF, Lindquist S, 2000. Nucleated Conformational Conversion and the Replication of Conformational Information by a Prion Determinant. Science 289: 1317-21.

146.    Satyal SH, Schmidt E, Kitagawa K, Sondheimer N, Lindquist S, Kramer JM, Morimoto RI, 2000. Polyglutamine aggregates alter protein-folding homeostasis in Caenorhabditis elegans. Proc Natl Acad Sci USA 97: 5750-55.

147.    Queitsch C, Hong S-W, Vierling E, Lindquist S, 2000. Hsp101 plays a crucial role in thermotolerance in Arabidopsis. The Plant Cell 12: 479-92.

148.    Krobitsch S, Lindquist S, 2000. Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins. Proc Natl Acad Sci USA 97: 1589-94.

149.    Sondheimer N, Lindquist S, 2000. Rnq1: an epigenetic modifier of protein function in yeast. Mol Cell 5: 1-20.

150.    Li L, Lindquist S, 2000. Creating a protein-based element of inheritance. Science 287: 661-64.

151.    Ma J, Lindquist S, 1999. De novo generation of a PrPSc-like conformation in living cells. Nat Cell Biol 1: 358-61.

152.    Liu J-J, Lindquist S, 1999. Oligopeptide-repeat expansions modulate ‘protein-only’ inheritance in yeast. Nature 400: 573-76.

153.    Scheibel T, Weikl T, Rimerman R, Smith D, Lindquist S, Buchner J, 1999. Contribution of N- and C-terminal domains to the function of hsp90 in Saccharomyces cerevisiae. Molecular Microbiology 34: 701-13.

154.    Yue L, Karr TL, Nathan DF, Swift H, Srinivasan S, Lindquist S, 1999. Genetic Analysis of Viable Hsp90 Alleles Reveals a Critical Role in Drosophila Spermatogenesis. Genetics 151: 1065-79.

155.    Zhou P, Derkatch IL, Uptain SM, Patino MM, Lindquist S, Liebman SW, 1999. The yeast non-Mendelian factor [ETA+] is a variant of [PSI+], a prion-like form of release factor eRF3. EMBO J 18: 1182-91.

156.    Newman GP, Wegrzyn RD, Lindquist SL, Chernoff YO, 1999. Antagonistic interactions between yeast chaperones Hsp104 and Hsp70 in prion curing. Mol Cell Biol 19: 1325-33.

157.    Nathan DF, Vos MH, Lindquist S, 1999. Identification of SSF1, CNS1, and HCH1 as multicopy suppressors of a Saccharomyces cerevisiae Hsp90 loss-of-function mutation. Proc Natl Acad Sci USA 96: 1409-14.    

158.    Xu Y, Singer M, Lindquist S, 1999. Maturation of the tyrosine kinase c-src as a kinase and as a substrate depends on the molecular chaperone Hsp90. Proc Natl Acad Sci USA 96: 109-14.

159.    Rutherford SL, Lindquist S, 1998. Hsp90 as a capacitor for morphological evolution. Nature 396: 336-42.

160.    Wang Z, Lindquist S, 1998. Developmentally regulated nuclear transport of transcription factors in Drosophila embryos enable the shock response. Development 125: 4841-50.

161.    Glover JR, Lindquist S, 1998. Hsp104, Hsp70 and Hsp40: a novel chaperone system that rescues previously aggregated proteins. Cell 94: 73-82. 

162.    Schirmer EC, Queitsch C, Kowal AS, Parsell DA, Lindquist S, 1998. The ATPase activity of Hsp104, effects of environmental conditions and mutations. J Biol Chem 273: 15546-52. 

163.    Lee K, Kang S, Lindquist S, 1998. 13C NMR studies of metabolic pathways regulated by HSP104 in Saccharomyces cerevisiae. Bull Korean Chem Soc 19: 295-99. 

164.    Duina AA, Marsh JA, Kurtz RB, Chang H-CJ, Lindquist S, Gaber RF, 1998.  The peptidyl-prolyl isomerase domain of the Cyp-40 cyclophilin homolog Cpr7 is not required to support growth or glucocorticoid receptor activity in Saccharomyces cerevisiae.  J Biol Chem 273: 10819-22.

165.    Singer MA, Lindquist S, 1998.  Multiple effects of trehalose on protein folding in vitro and in vivo.  Mol Cell 1: 639-48.

166.    DebBurman SK, Raymond GJ, Caughey B, Lindquist S, 1997.  Chaperone-supervised conversion of prion protein to its protease-resistant form. Proc Natl Acad Sci USA 94: 13938-43.

167.    Schirmer EC, Lindquist S, 1997.  Interactions of the chaperone Hsp104 with yeast Sup35 and mammalian PrP. Proc Natl Acad Sci USA 94: 13932-37.

168.    Nathan DF, Vos MH, Lindquist S, 1997.  In vivo functions of the Saccharomyces cerevisiae Hsp90 chaperone. Proc Natl Acad Sci USA 94: 12949-56.  (Inaugural Article)

169.    Golic MM, Rong YS, Petersen RB, Lindquist SL, Golic KG, 1997. FLP-mediated DNA mobilization to specific target sites in Drosophila chromosomes.  Nucl Acids Res 25: 3665-71.

170.    Kimura Y, Rutherford SL, Miyata Y, Yahara I, Freeman BC, Yue L, Morimoto RI, Lindquist S, 1997.  Cdc37 is a molecular chaperone with specific functions in signal transduction. Genes Dev 11: 1775-85.

171.    Glover JR, Kowal AS, Schirmer EC, Patino MM, Liu J-J, Lindquist S, 1997. Self-seeded fibers formed by Sup35, the protein determinant of [PSI+], a heritable prion-like factor of Saccharomyces cerevisiae. Cell 89: 811-19.

172.    Chang H-CJ, Nathan DF, Lindquist S, 1997. In vivo analysis of the Hsp90 co-chaperone Sti1 (p60).  Mol Cell Biol 17: 318-25.

173.    Duina AA, Chang H-CJ, Marsh JA, Lindquist S, Gaber RF, 1996. A cyclophilin function in Hsp90-mediated signal transduction. Science 274: 1713-15. 

174.    Patino MM, Liu J-J, Glover JR, Lindquist S, 1996. Support for the prion hypothesis for inheritance of a phenotypic trait in yeast. Science 273: 622-26.

175.    Feder ME, Cartano NV, Milos L, Krebs RA, Lindquist SL, 1996. Effect of engineering Hsp70 copy number on Hsp70 expression and tolerance of ecologically relevant heat shock in larvae and pupae of Drosophila melanogaster. J Exp Biol 199: 1837-44.

176.    Lindquist S, Kim G, 1996. Hsp104 expression is sufficient for thermotolerance in yeast. Proc Natl Acad Sci USA 93: 5301-06.

177.    Welte MA, Duncan I, Lindquist S, 1995. The basis for a heat-induced developmental defect: defining crucial lesions. Genes Dev 9: 2240-50.

178.    Nathan D, Lindquist S, 1995. Mutational analysis of hsp90 function: interactions with a steroid receptor and a protein kinase. Mol Cell Biol 15: 3917-25.

179.    Kimura Y, Yahara I, Lindquist S, 1995. The role of the protein chaperone YDJ1 in establishing HSP90-mediated signal transduction pathways. Science 268: 1362-65.

180.    Chernoff YO, Lindquist SL, Ono B-I, Inge-Vechtomov SG, Liebman SW, 1995. Role of the chaperone protein Hsp104 in propagation of the yeast prion-like factor [PSI+]. Science 268: 880-84.

181.    Vogel JL, Parsell DA, Lindquist S, 1995. The heat-shock proteins hsp104 and hsp70 reactivate mRNA splicing after heat-inactivation. Curr Biol 5: 306-17.

182.    Schirmer EC, Lindquist S, Vierling E, 1994. An Arabidopsis heat-shock protein complements a thermotolerance defect in yeast. The Plant Cell 6: 1899-09. 

183.    Parsell D, Kowal A, Singer MA, Lindquist S, 1994. Protein disaggregation mediated by heat-shock protein HSP104. Nature 372: 475-78.

184.    Chang H-CJ, Lindquist S, 1994. Conservation of hsp90 macromolecular complexes in Saccharomyces cerevisiae. J Biol Chem 269: 24983-88.

185.    Dellavalle R, Petersen R, Lindquist S, 1994. Preferential deadenylation of hsp70 mRNA plays a key role in regulating hsp70 expression in Drosophila melanogaster. Mol Cell Biol 14: 3646-59.

186.    Parsell DA, Kowal AS, Lindquist S, 1993. The S. cerevisiae Hsp104 protein: Purification and characterization of ATP-induced structural changes. J Biol Chem 269: 4480-87.

187.    Welte MA, Tetrault JM, Dellavalle RP, Lindquist SL, 1993. A new method for manipulating transgenes: Engineering heat tolerance in a complex multicellular organism. Curr Biol 3: 842-53.

188.    Hotchkiss R, Nunnally I, Lindquist S, Taulien J, Perdrizet G, Karl I, 1993. Hyperthermia protects mice against the lethal effects of endotoxin. Amer J Physiol R1447-R1457. 

189.    Sanchez Y, Parsell DA, Taulien J, Vogel JL, Craig EA, Lindquist S, 1993. Genetic evidence for a functional relationship between Hsp104 and Hsp70. J Bact 175: 6484-91.

190.    Xu Y, Lindquist S, 1993.  Heat-shock protein hsp90 governs the activity of pp60v-src kinase. Proc Natl Acad Sci USA 90: 7074-78.

191.    Feder JH, Rossi JM, Solomon J, Solomon N, Lindquist S, 1992. The consequences of expressing hsp70 in Drosophila cells at normal temperatures. Genes Dev 6: 1402-13.

192.    Sanchez Y, Taulien J, Borkovich KA, Lindquist S, 1992. Hsp104 is required for tolerance to many forms of stress. EMBO J 11: 2357-64.

193.    Solomon JM, Rossi JM, Golic K, McGarry T, Lindquist S, 1991. Changes in Hsp70 alter thermotolerance and heat-shock regulation in Drosophila. The New Biologist 3: 1106-20.

194.    Parsell DA, Sanchez Y, Stitzel JD, Lindquist S, 1991. Hsp104 is a highly conserved protein with two essential nucleotide-binding sites. Nature 353: 270-73.

195.    Welsh N, Welsh M, Lindquist S, Eizirik DL, Bendtzen K, Sandler S, 1991.  Interleukin-1ß increases the biosynthesis pf the heat shock protein hsp70 and selectively decreases the biosynthesis of five proteins in rat Pancreatic islets. Autoimmun 9: 33-40.

196.    Yost HJ, Lindquist S, 1991. Heat shock proteins affect RNA processing during the heat shock response of Saccharomyces cerevisiae. Mol Cell Biol 11: 1062-68.

197.    Susek RE, Lindquist S, 1990.  Transcriptional derepression of the Saccharomyces cerevisiae HSP26 gene during heat shock. Mol Cell Biol 10: 6362-73.

198.    Picard D, Khursheed B, Garabadian MJ, Fortin MG, Lindquist S, Yamamoto K, 1990. Reduced levels of hsp90 compromise receptor action in vivo. Nature 348: 166-68.

199.    Sanchez Y, Lindquist S, 1990.  HSP104 required for induced thermotolerance. Science 248: 1112-15.

200.    Lindquist S, Petersen R, 1990.  Selective translation and degradation of heat-shock messenger RNAs in Drosophila. Enzyme 44: 147-66.

201.    Petersen R, Lindquist S, 1989. Regulation of HSP70 synthesis by messenger RNA degradation. Cell Regulation 1: 135-49.

202.    Golic K, Lindquist S, 1989.  The FLP recombinase of yeast catalyzes site-specific recombination in the Drosophila genome. Cell 59: 499-509.

203.    Susek R, Lindquist S, 1989.  Hsp26 of Saccharomyces cerevisiae is homologous to the superfamily of small heat shock proteins, but is without a demonstrable function. Mol Cell Biol 9: 5265-71.

204.    Borkovich K, Farrelly FW, Finkelstein DB, Taulien J, Lindquist S, 1989. HSP82 is an essential protein that is required by cells in higher concentrations for growth at higher temperatures. Mol Cell Biol 9: 3919-30.

205.    Rossi JM, Lindquist SL, 1989. The intracellular location of yeast HSP26 varies with metabolism. J Cell Biol 108: 425-39. 

206.    Yost HJ, Lindquist SL, 1988. Translation of unspliced transcripts after heat shock. Science 242: 1544-48.

207.    Wu CH, Caspar T, Browse J, Lindquist S, Somerville C, 1988. Characterization of an HSP70 Cognate Gene Family in Arabidopsis. Plant Physiol 88: 731-40. 

208.    Petersen RB, Lindquist S, 1988. The Drosophila hsp70 message is rapidly degraded at normal temperatures and stabilized by heat shock. Gene 72: 161-68.

209.    Gordon ED, Lindquist S, 1987. Hypusine formation in eukaryotic initiation factor 4D is not reversed when rates of specificity of protein synthesis is altered. J Biol Chem 262: 16590-95. 

210.    Gordon ED, Lindquist S, 1987. Eukaryotic initiation factor 4D, the hypusine-containing protein, is conserved among eukaryotes. J Biol Chem 262: 16585-89.

211.    Kurtz S, Lindquist S, 1986. Subcellular differentiation in sporulating yeast. Cell 45: 771-79.

212.    Petko L, Lindquist S, 1986. HSP26 is not required for growth at high temperatures, nor for thermotolerance, spore development or germination. Cell 45: 885-94.

213.    Yost HJ, Lindquist SL, 1986. RNA splicing is interrupted by heat shock and rescued by heat shock protein synthesis. Cell 45: 185-93.

214.    Kurtz S, Rossi J, Petko L, Lindquist SL, 1986. An ancient developmental induction: same heat-shock proteins in Saccharomyces sporulation and Drosophila oogenesis. Science 231: 1154-57.

215.    McGarry TJ, Lindquist SL, 1986. Inhibition of heat shock protein synthesis by heat-inducible antisense RNA. Proc Natl Acad Sci USA 83: 399-404.

216.    McGarry TJ, Lindquist SL, 1985. The preferential translation of Drosophila hsp70 mRNA requires sequences in the untranslated leader. Cell 42: 903-11.

217.    Pelham H, Lewis M, Lindquist S, 1985. Expression of a Drosophila heat shock protein in mammalian cells: transient association with nucleoli after heat shock. Phil Trans R Soc Lond B 307: 301-07. 

218.    Kurtz S, Lindquist SL, 1984. The changing pattern of gene expression in sporulating yeast. Proc Natl Acad Sci USA 81: 7323-27.

219.    Velazquez JM, Lindquist SL, 1984. HSP70: nuclear function during environmental stress; cytoplasmic storage during recovery. Cell 36: 655-62.

220.    Velazquez JM, Sonoda S, Lindquist SL, 1983. Is the major Drosophila heat shock protein present in cells that have not been heat shocked? J Cell Biol 96: 286-90.

221.    DiDomenico BJ, Bugaisky G, Lindquist SL, 1982. The heat shock response is self-regulated at both the transcriptional and post-transcriptional levels. Cell 31: 593-603. 

222.    DiDomenico BJ, Bugaisky G, Lindquist SL, 1982. Heat shock and recovery are mediated by different translational mechanisms. Proc Natl Acad Sci USA 78: 3531-35.

223.    Lindquist S, 1981.  Regulation of protein synthesis during heat shock. Nature 293: 311-14.

224.    Velazquez JM, DiDomenico BJ, Lindquist SL, 1980. Intracellular localization of heat shock proteins in Drosophila. Cell 20: 67 Cold Spring Harb Perspect Biol9-89.

225.    Lindquist SL, 1980. Translation efficiency of heat-induced messages in Drosophila melanogaster cells. J Mol Biol 137: 151-58.

226.    Lindquist SL, 1980. Varying patterns of protein synthesis during heat shock: implications for regulation. Dev Biol 77: 463-79.

227.    McKenzie SL , Meselson M, 1977. Translation in vitro of Drosophila heat-shock messages. J Mol Biol 117: 279-83.

228.    McKenzie SL1, Henikoff S, Meselson M, 1975. Localization of RNA from heat-induced polysomes at puff sites in Drosophila melanogaster. Proc Natl Acad Sci USA 72: 1117-21.


1.    Narayan P, Ehsani S, Lindquist S, Combatting neurodegenerative disease with chemical probes and model systems, Nat Chem Bio, 10: 911-20.

2.    Tardiff DF, Khurana V, Chung CY, Lindquist S, 2014. From yeast to patient neurons and back again: powerful new discovery platforms. Movement Disorders, 29(10): 1231-40.

3.    Valastyan JS, Lindquist S, 2014. Protein folding disease mechanisms at a glance. DMM, 7(1):9-14.

4.    Newby GA, Lindquist S, 2013. Blessings in disguise: biological benefits of prion-like mechanisms. TCB 23(6): 251-9.

5.    Lindquist SL, Kelly JW, 2011.  Chemical and biological approaches for adapting proteostasis to ameliorate protein misfolding and aggregation diseases—progress and prognosis. In Cold Spring Harb Perspect Biol. RI Morimoto, DJ Selkoe, JW Kelly, eds.  Cold Spring Harbor Laboratory Press, NY, Sept 7. pii: cshperspect.a004507v1. doi: 10.1101/cshperspect.a004507 [Epub ahead of print].

6.    Jarosz DF, Taipale M, Lindquist S, 2010. Protein homeostasis and the phenotypic manifestation of genetic diversity: principles and mechanisms. Ann Rev Genet 44: 189-216.

7.    Halfmann R, Lindquist S, 2010. Epigenetics in the extreme: Prions and the inheritance of environmentally acquired traits. Science 330: 629.

8.    Lindquist S, 2010. Three quite different things that matter to me. Mol Biol Cell 21: 3804.

9.    Taipale M, Jarosz DF, Lindquist S, 2010. HSP90 at the hub of protein homeostasis: emerging mechanistic insights. Nat Rev Mol Cell Biol 11: 515-28.

10.    Auluck PK, Caraveo G, Lindquist S, 2010. Alpha-Ssynuclein: Membrane Iiteractions and toxicity in Parkinson's disease. Ann Rev Cell Dev Biol 26: 211–33.

11.    Khurana V, Lindquist S, 2010. Modelling neurodegeneration in Saccharomyces cerevisiae: why cook with baker's yeast?  Nat Rev Neurosci 11: 436-49. 

12.    Alberti S, Halfmann R, Lindquist S, 2010. Biochemical, cell biological, and genetic assays to analyze amyloid and prion aggregation in yeast. Methods Enzymol 470: 709-34.

13.    Tessier PM, Lindquist S, 2010. Unraveling molecular mechanisms and structures of self-perpetuating prions.  In Protein Misfolding Diseases: Basis of Protein Misfolding, Pathophysiology, Current, and Emerging Therapies.  M Ramirez-Alvarado, JW Kelly, CM Dobson (Eds).  John Wiley & Sons, Inc. Hoboken, NJ, pp. 145-174.

14.    Halfmann R, Lindquist S, 2010.  Prions, protein homeostasis, and phenotypic diversity. Trends Cell Biol 3:125-33.

15.    Lindquist S, 2009. Protein Folding Sculpting Evolutionary Change. Cold Spring Harbor Symposia on Quantitative Biology 74: Evolution: The Molecular Landscape. Cold Spring Harbor Press, Cold Spring Harbor, NY. pp. 103-108.

16.    Tessier PM, Lindquist S, 2009. Unraveling infectious structures, strain variants and species barriers for the yeast prion [PSI+]. Nat Struct Mol Biol 16: 598-605.  

17.    Treusch S, Cyr DM, Lindquist S, 2009. Amyloid deposits:  Protection against toxic protein species? Cell Cycle 8: 1668-74.

18.    Whitesell L, Lindquist S, 2009. Inhibiting the transcription factor HSF1 as an anticancer strategy.  Expert Opinion on Therapeutic Targets 13: 469-478.

19.    Lindquist S, Allendoerfer KL, 2009. Simple Cellular Solutions to Complex Problems.  In Intracellular Traffic and Neurodegenerative Disorders. PH St. George-Hyslop, WC Mobley, Y Christen, eds.  Springer-Verlag, Berlin Heidelberg, pp. 41-58.

20.    Fleming J, Outiero TF, Slack M, Lindquist SL, Bulawa CE, 2008. Detection of compounds that rescue rab1-synuclein toxicity.  Methods Enzymol 439: 339-51.

21.    Allendoerfer KL, Su LJ, Lindquist S, 2008. Yeast Cells as a Discovery Platform for Parkinson’s Disease and Other Protein Misfolding Diseases.  In Parkinson’s Disease:  Molecular and Therapeutic Insights from Model Systems. R Nass & S Przedborski, eds.  Academic Press, NY, pp. 505-536.

22.    Steele AD, Lindquist S, Aguzzi A, 2007. The Prion Protein Knockout Mouse, A Phenotype Under Challenge.  Prion 1: 83-93.

23.    Whitesell L, Lindquist SL, 2005. Hsp90 and the Chaperoning of Cancer. Nat Rev Cancer 5: 761-72.

24.    Shorter J, Lindquist SL, 2005. Prions as adaptive conduits of memory and inheritance. Nat Rev Genet 6: 435-50.

25.    Singer MA, Outeiro TF, Lindquist SL, 2005. Stress Tolerance, Metabolism and Development:  The Many Flavors of Trehalose.  In Food Biotechnology, 2nd edition.  K Shetty, G Paliyath, A Pometto, RE Levin, eds. CRC Press, Boca Raton, FL, pp. 311-328.

26.    Sangster TA, Lindquist S, Queitsch C, 2004. Under Cover: causes, effects and implications of Hsp90-mediated genetic capacitance.  Bioessays 26: 348-62.

27.    Rochet JC, Outeiro TF, Conway KA, Ding TT, Volles MJ, Lashuel HA, Bieganski RM, Lindquist SL, Lansbury PT, 2004.  Interactions Among alpha-Synuclein, Dopamine, and Biomembranes: Some Clues for Understanding Neurodegeneration in Parkinson’s Disease.  J Mol Neurosci 23: 23-24.

28.    Sangster TA, Queitsch C, Lindquist S, 2003. Hsp90 and Chromatin: Where is the Link? Cell Cycle 2: 166-68.

29.    Lindquist SL, Henikoff S, 2002. Self-perpetuating structural states in biology, disease, and genetics. Proc Natl Acad Sci USA 99: 16377.

30.    Uptain SM, Lindquist S, 2002. Prions as Protein-Based Genetic Elements.  Ann Rev Microbiol 56: 703-41.

31.    Serio T, Lindquist S, 2002. The Yeast Prion [PSI+]:  Molecular Insights and Functional Consequences. Advances in Protein Chemistry 59: 391-412.

32.    Lindquist S, Krobitsch S, Li L, Sondheimer N, 2001. Investigating protein conformation-based inheritance and disease in yeast.  Philosophical Transactions of the Royal Society B: Biological Sciences 356: 169-76.

33.    Serio TR, Cashikar AG, Kowal AS, Sawicki GJ, Lindquist SL, 2001. Self-Perpetuating changes in Sup35 protein conformation as a mechanism of heredity in yeast. Biochem Soc Sym 68: 35-43.

34.    Serio T, Lindquist S, 2001. [PSI+]. Sup35, and Chaperones. Advances in Protein Chemistry 57: 335-66. 

35.    Serio TR, Lindquist SL, 2000. Protein-only inheritance in yeast: something to get [PSI+]-ched about.  Trends in Cell Biology 10: 98-105. 

36.    Serio TR, Cashikar AG, Moslehi JJ, Kowal, AS, Lindquist S, 1999. Yeast prion [+] and its determinant, Sup35p. Methods Enzymol 309: 649-73.

37.    Serio TR, Lindquist SL, 1999. [PSI+]: An epigenetic modulator of translation termination efficiency. Ann Rev Cell Dev Biol 15: 661-703.

38.    Lindquist S, Schirmer EC, 1999. The role of Hsp104 in stress tolerance and prion maintenance.  In Molecular Chaperones and Folding Catalysts:  Regulation, Cellular Function, and Mechanisms. B Bukau, ed.  Harwood Academic Publishers, Newark NJ. pp. 347-380.

39.    Schirmer EC, Lindquist S, 1998. Purification and properties of Hsp 104 from yeast. In Methods  Enzymol, Vol. 290. Academic Press, New York, NY.  pp. 430-444.

40.    Caughey B, Chabry J, Demaimay R, Herrmann LM, Horiuchi M, Raymond LD, Raymond GJ, Caughey WS, DebBurman SK, Lindquist S, Chesebro B, 1999.  Formation of protease-resistant prion protein in vitro: stimulation and inhibition. Alzheimer’s Disease and Related Disorders, K Iqbal, DF Swaab, B Winblad, and HM Wisniewski, eds. John Wiley & Sons Ltd. pp. 581-587. 

41.    Singer MA, Lindquist S, 1998. Thermotolerance in Saccharomyces cerevisiae: The yin and yang of trehalose.  Trends Biotech 16: 460-68.

42.    Glover JR, Schirmer EC Singer MA, Lindquist S, 1998. Hsp104 in Molecular Chaperones in the Life Cycle of Proteins: Structure, Function, and Mode of Action. AL Fink, Y Goto, eds.  Marcel Dekker, Inc. pp. 193-224.

43.    Lindquist S, DebBurman SK, Glover JR, Kowal AS, Liu JJ, Schirmer EC, Serio TR, 1998.  Amyloid fibres of Sup35 support a prion-like mechanism of inheritance in yeast. Biochem Soc Trans 26(3): 486-90.

44.    Lindquist S, 1997. Mad cows meet psi-chotic yeast: The expansion of the prion hypothesis. Cell 89: 495-98. 

45.    Lindquist S, Patino MM, Chernoff YO, Kowal AS, Singer MA, Liebman SW, Lee K-H, Blake T, 1995.  The role of Hsp104 in stress tolerance and [PSI+] propagation in Saccharomyces cerevisiae.  Cold Spring Harbor Symposia on Quantitative Biology 60: Protein Kinesis, Vol. LX.  Cold Spring Harbor Press, Cold Spring Harbor, NY.  pp. 451-460.

46.    Lindquist S, 1996. Mad cows meet mad yeast: the prion hypothesis.  Molecular Psychiatry 1: 376-79.

47.    Tuite M, Lindquist S, 1996.The maintenance and inheritance of yeast prions. Trends Genet 12: 467-71.

48.    Schirmer EC, Glover JR, Singer MA, Lindquist S, 1996. HSP100/Clp proteins: A common mechanism explains diverse functions. Trends Biochem Sci 21:289-296.

49.    Feder ME, Parsell DA, Lindquist SL, 1994. The stress response and stress proteins in Cell Biology of Trauma, Chapter 12.  JJ Lemasters, C Oliver, eds. CRC Press, Inc., Boca Raton, FL.  pp. 177-191.

50.    Parsell DA, Lindquist S, 1994. Heat shock proteins and stress tolerance in The Biology of Heat Shock Proteins and Molecular Chaperones.  RE Morimoto, A Tissieres, C Georgopoulos, eds.  Cold Spring Harbor Press, Cold Spring Harbor, NY. pp. 457-494.

51.    Lindquist S, Parsell D, Sanchez Y, Taulien J, Craig EA, Welte M, 1993. Heat-shock proteins in stress tolerance in Journal of UOE, 15, XIIth UOEH Int. Symp. Stress Proteins, Nov. 17-18, 1992, Kitakyushu, Japan.

52.    Parsell D, Lindquist S, 1993. The function of heat-shock proteins in stress tolerance: degradation and reactivation of damaged proteins. Ann Rev Genet 27: 437-96.

53.    Lindquist S, 1993. Autoregulation of the heat shock response in Translational Regulation of Gene Expression II. J. Ilan, ed.  Plenum Press, NY.  pp. 279-320.

54.    Parsell DA, Taulien J, Lindquist S, 1992. The role of heat-shock proteins in thermotolerance in Philosophical Transactions of the Royal Society of London, Series B.   RJ Ellis, RA Laskey, GH Lorimer, eds. The Royal Society, London 339: 279-286.

55.    Lindquist S, 1992. Heat-shock proteins and stress tolerance in microorganisms. Curr Opin Gen & Dev  2: 748-55.

56.    Lindquist S, 1992.  DnaJ and DnaK:  Won't you change partners and dance? Curr Biol 2:119-121.

57.    Lindquist S, 1990.  Genetic analysis of heat shock protein functions in yeast in Heat Shock.  B. Maresca, S Lindquist, eds.  Springer-Verlag, Berlin.  pp. 123-132.

58.    Petersen RB, Lindquist S, 1990. Differential mRNA stability: a regulatory strategy for Hsp70 synthesis in Post-Transcriptional Control of Gene Expression. JEG McCarthy, MF Tuite, eds.  Springer-Verlag, Berlin. pp. 83-91.

59.    Petersen R, Lindquist S, 1990. Selective translation and degradation of heat-shock messenger RNAs in Drosophila in Translationally Regulated Genes in Higher Eukaryotes. RE Thatch, ed.  Enzyme 44: 147-166.

60.    Yost HJ, Petersen RB, Lindquist S, 1990. RNA metabolism: strategies for regulation in the heat shock response. Trends Genet 6: 223-27.

61.    Yost HJ, Petersen, RB, Lindquist S, 1990. Post-transcriptional regulation of heat shock protein synthesis in Drosophila in Stress Proteins in Biology and Medicine. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.  pp. 379-409.

62.    Lindquist S, DebBurman SK, Glover JR, Kowal AS, Liu J-J, Schirmer EC, Serio TR, 1988. Amyloid fibres of Sup35 support a prion-like mechanism of inheritance in yeast. Biochem Soc Trans 26: 486-90.  

63.    Lindquist S, McGarry TJ, Golic K, 1988. Use of antisense RNA in studies of the heat-shock response in Antisense RNA and DNA.  DA Melton, ed. Cold Spring Harbor Press, Cold Spring Harbor, NY. 

64.    Lindquist S, Craig E, 1988. The Heat-shock proteins.  Ann Rev Genet   22:263-277.**
** One of the 10 most cited papers in the field of Genetics, 1990.

65.    Lindquist S, 1987. Translational regulation in the heat-shock response of Drosophila cells in Translational Regulation of Gene Expression, J Ilan, ed.  Plenum Press, NY.   pp. 187-207.  

66.    McGarry TJ, Lindquist SL, 1986. Translational control of heat shock proteins in Drosophila in The Translational Control of Protein Synthesis.  M Matthews, ed. Cold Spring Harbor Press, Cold Spring Harbor, NY. pp. 86-90. 

67.    Kurtz S, Rossi J, Lindquist SL, 1986. Gene expression during sporulation in Yeast Cell Biology UCLA Symposium.  J Hicks, ed., Alan R. Liss, New York, NY. pp. 159-172. 

68.    Lindquist SL, 1986. The heat shock response. Ann Rev Biochem 55: 1151-91.

69.    Lindquist SL, 1985. The heat-shock response: different means to the same end.  Microbiology '85  pp. 332-335.

70.    Kurtz S, Gordon E, Lindquist SL, 1985. RNA metabolism during sporulation in Sequence Specificity in Transcription and Translation. UCLA Symposium. L Gold, R Calendar, eds. pp. 611-620.

71.    Sirkin E, Lindquist SL, 1985. Translational regulation in the Drosophila heat shock response in Sequence Specificity in Transcription and Translation. UCLA Symposium.  L Gold, R Calendar, eds. pp. 669-680.

72.    Lindquist SL, DiDomenico BJ, 1985. Coordinate and non-coordinate expression of heat shock proteins: a model for regulation in Changes in Eukaryotic Gene Expression in Response to Environmental Stress.   B. G Atkinson, DB Walden, eds. Academic Press, NY.  pp. 71-89.

73.    Lindquist SL, 1985. Heat shock--a comparison of Drosophila and yeast. J Embryol Exp Morph 83: 147-61.

74.    Lindquist SL, DiDomenico BJ, Bugaisky G, et al., 1982.  "Regulation of the heat shock response in Drosophila and yeast" in Heat Shock from Bacteria to Man.   MJ Schlesinger, M Ashburner, A Tessieres, eds. Cold Spring Harbor Press, Cold Spring Harbor, NY.pp. 167-175. 

Books Edited

Heat Shock. 1990. B Maresca, S Lindquist, eds.  Springer-Verlag, Berlin.

The Stress Induced Proteins. 1988. ML Pardue, JR Feramisco, S Lindquist, eds. Alan R. Liss, Inc., New York.  pp. 294.


Methods for identifying factors that control the folding of amyloid proteins of diverse origin. Lindquist S. US (7,799,535)

Yeast screens for the treatments of human disease. Lindquist S, Krobitsch S, Outeiro T. US (8,039,209) Australia (2011200744) Canada (2,438,661) Japan (5152977) Europe (1793001)

Methods of identifying lead compounds that modulate toxicity of neurotoxic polypeptides. Lindquist S, Outeiro T, Muchowski P. US (8,735,072)

Compositions and methods for treatment of protein misfolding diseases. Lindquist S, Outeiro T. (Pending)
Compounds, compositions and methods of inhibiting alpha-synuclein toxicity. Lindquist S, Outeiro T, Labaudiniere R, Fleming J, Bulawa C, Weigel C, Liang F, Gupta S, Ripka A. US (8,440,705)

Compositions and methods for treatment of protein misfolding diseases. Lindquist S, Duennwald M. US (8,192,986)

Hsp90, buffering and drug resistance. Lindquist S, Cowen L. US (8,343,913)

Modulators of alpha-synuclein toxicity. Lindquist S, Cashikar A, Gitler A, Cooper A, Haynes C. US (8,501,465)

Yeast cells expressing TAR DNA-binding protein 43 and uses therefor. Lindquist S, Gitler A. US (pending) Europe (2262895)

Yeast cells expressing amyloid beta and uses therefor. Lindquist S, Matlack K. (pending)
Withaferin A analogs and uses thereof. Lindquist S, Whitesell L, Gunatilaka L, Xu Y, Dennis R, Kithsiri E. (pending)

Bacteriophages expressing amyloid peptides and uses thereof. Lindquist S, Lu T, Krishnan R, Collins J, O’Donnell, Leighton B, Devadas S. (pending)

Chaperone interaction assays and uses thereof. Lindquist S, Taipale M. US (pending) Israel (pending) Europe (pending)

Yeast cells expressing amyloid beta and uses therefor. Lindquist S, Truesch S, Matlack K. (pending)

HSF1 as a marker in tumor prognosis and treatment. Lindquist S, Ince T, Santagata S, Whitesell L. (pending)

HSF1 as a marker in tumor prognosis and treatment. Lindquist S, Mendillo M, Sanagata S, Whitesell L. (pending)

Compounds for treating infectious diseases. Lindquist S, McLellan C, Whitesell L, Mazitschek R. (pending)

Prion-based manipulation of yeast fermentation and growth. Lindquist S, Brown J, Jarozx D, Walker G. (pending)

Thiohydantoin derivatives and uses thereof. Lindquist S, Vincent B, Youngsaye W,Whitesell L, Langlois J, Buchwald S, Pu J, Munoz B, Dandapani S. (pending)

Indazole derivatives and uses thereof. Lindquist S, Vincent B, Whitesell L, Youngsaye W, Buchwald S, Langlois J, Srinivas R, Tidor B, Nag P, Ting A, Morgan B, Munoz B, Dandapani S. (pending)

Heritable remodeling of yeast multicellularity by an environmentally responsive prion. Lindquist S, Halfmann R, Holmes D, Lancaster A. (Disclosure only- No Filings)

Cellular discovery playform for neurodegenerative diseases. Lindquist S, Khurana V, Chung C. (pending)

Amyloid beta expression constructs and uses therefor. Lindquist S, Haque A. (pending)

Cells expressing apolipoprotein E and uses thereof. Lindquist S, Narayan P. (pending)

HSF1 in tumor stroma. Lindquist S, Scherz-Shouval R, Santagata S, Whitesell L. (pending)

Hybridoma for 7FB (monoclonal anti-Hsp70 antibody). Lindquist S. (Disclosure only – No filings)