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Mechanisms of Gene Expression 

Chromatin structure and epigenetic modifications and maintenance of the genome:

  • Chairs: Ann Ehrenhofer-Murray (Berlin, Germany), Carl Wu (Ashburn, United States)
  • Carl Wu (Ashburn, United States): Chromatin dynamics of histone variant H2A.Z at yeast gene promoters
  • Ann Ehrenhofer-Murray (Berlin, Germany): Regulation of centromere function by posttranslational modifications on the centromeric histone variant CENP-A/ Cse4 in yeast
  • Jane Mellor (Oxford, United Kingdom): Epigenetic control of translation and ageing
  • Francesc Posas Garriga (Barcelona, Spain): Coordination of gene expression and cell cycle progression in response to stress
  • Sebastian Meijsing (Berlin, Germany): How do transcription factors “know” where to go in the genome?
  • Gábor Szabó (Debrecen, Hungary): The effect of histone modifications and DNA superhelicity on nucleosome stability
  • Robin Allshire (Edinburgh, United Kingdom): Epigenetic transmission: establishment and inheritance of specialised chromatin
  • Andrés Aguilera (Sevilla, Spain): RNA:DNA hybrids as modulators of chromatin structure and genome instability
  • Juli Feigon (Los Angeles, United States): The Architecture of Tetrahymena Telomerase Holoenzyme
  • Piet Borst (Amsterdam, Netherlands): The sequence requirements for base J in DNA
  • Thomas Grundström (Umeå, Sweden): Signal regulated localisation of a mutagenic protein complex at the Igh locus

Turning signals into messages – the complexity of gene regulation: 

  • Chairs: Chirstine Blattner (Karlsruhe, Germany), Frank C.P. Holstege (Utrecht, Netherlands)
  • Dirk Schübeler (Basel, Switzerland): Sequence and chromatin determinants of DNA methylation
  • Shiv Grewal (Bethesda, United States): Epigenetic genome control by RNA processing factors and heterochromatin machinery
  • Edda Schulz (Berlin, Germany): Disentangling the gene-regulatory network controlling mono-allelic and female-specific expression of Xist at the onset of X-chromosome inactivation
  • Tatiana Marquez Lago (Onna-son, Japan): Non-classic effects in stochastic gene expression
  • Chirstine Blattner (Karlsruhe, Germany): The estrogen-inducible finger-protein TRIM25 controls p53 abundance and activity
  • Frank C.P. Holstege (Utrecht, Netherlands): Analysing regulatory circuitry by genome-wide perturbation analyses

Translational control and protein turnover:

  • Chair: David Ron (Cambridge, United Kingdom)
  • Nenad Ban (Zurich, Switzerland): Structural views on translation
  • Ramanunjan Hegde (Cambridge, United Kingdom): Mechanisms for detecting and degrading mislocalized proteins
  • Gesine Behrens (Hannover, Germany): Functional characteristics of a translational silencing element in the mRNA of IκBζ
  • Ekaterina Sheshukova (Moscow, Russian Federation): A short internal ORF in the leaf necrosis associated factor gene encodes a novel peptide controlling maternal mRNA accumulation
  • David Ron (Cambridge, United Kingdom): Control of protein synthesis by the integrated stress response
  • Philippe Pierre (Marseille, France): PKR-dependent translational arrest versus type-I Interferon production
  • Alexander Mankin (Chicago, United States): Antiobiotics and translation
  • Niccholas Ingolia (San Francisco, United States): Genome-wide translational profiling
  • Patrick Murphy (Sheffield, United Kingdom): Determining protein-protein interactions between translation initiation factors eIF2 and eIF2B
  • Antonis Koromilas (Montreal, Canada): mTORC2 balances Akt activation and eIF2α serine 51 phosphorylation to promote survival under stress
  • Zoya Ignatova (Potsdam, Germany): tRNA function in adaptive translation and disease

RNA processing and modifications:

  • Chairs: Mark Helm (Mainz, Germany), Chuan He (Chicago, United States)
  • Andrzej Dziembowski (Warszaw, Poland): Ribonuclease DIS3 shapes the RNA polymerase II transcriptome in humans
  • Sebastian Kadener (Jerusalem, Israel): Biogenesis and function of circRNAs
  • Gabriele Nübel (Heidelberg, Germany): LC-MS analysis for the qualitative and quantitative analysis of cellular modified NAD-RNA
  • Mark Helm (Mainz, Germany): RNA modification – detection, quantification, and function
  • Chuan He (Chicago, United States): Reversible RNA methylation in gene expression regulation

Non-coding RNAs in gene regulation: 

  • Chairs: Nikolaus Rajewsky (Berlin, Germany), Thomas Tuschl (New York, United States)
  • Eric Miska (Cambridge, United Kingdom): Transgenerational epigenetic inheritance and RNAe
  • Nick Watkins (Newcastle upon Tyne, United Kingdom): The 5S RNP connects ribosome production to cellular signalling
  • Claus Kuhn (Bayreuth, Germany): On-enzyme refolding permits small RNA and tRNA surveillance by the CCA-adding enzyme
  • D. Bunina: The impact of antisense transcription on protein abundance in yeast
  • Christine Mayr (New York, United States): Regulation of protein localization and function by alternative 3’UTRs
  • Nikolaus Rajewsky (Berlin, Germany): Regulatory RNAs
  • Mikiko C. Siomi (Tokyo, Japan): PIWI-intracting RNA in Drosophila; its biogenesis and function
  • Sir David Baulcombe (Cambridge, United Kingdom): RNA silencing and regulation at the epigenetic and translational levels
  • Olga Burenina (Moscow, Russian Federation): Comparative transcriptome and proteome analyses of Bacillus subtilis 6S-1 and 6S-2 RNAs deletion strains
  • Michal Lubas (Copenhagen, Denmark): Biochemical characterization of long non-coding RNAs
  • Thomas Tuschl (New York, United States): Human RNA sequencing analysis for research, diagnostic and prognostic studies